Reference Material

KEY CELL FACTORS*

SymbolGene Summary RegulationLink
ARhormoneshttps://pubchem.ncbi.nlm.nih.gov/gene/367
BMP-2bone, cartilagehttps://pubchem.ncbi.nlm.nih.gov/gene/650
BMP-4hearthttps://pubchem.ncbi.nlm.nih.gov/gene/652
BMP-5metabolismhttps://pubchem.ncbi.nlm.nih.gov/gene/653
BMP-7bone, cartilage and musclehttps://pubchem.ncbi.nlm.nih.gov/gene/655
GDF-11nervous, organ systems, aginghttps://pubchem.ncbi.nlm.nih.gov/gene/10220
GDF-15inflammation, cell repair, growth, oxid stresshttps://pubchem.ncbi.nlm.nih.gov/gene/9518
NTF-3central nervous systemhttps://pubchem.ncbi.nlm.nih.gov/gene/4908
NTF-4peripheral nervous systemhttps://pubchem.ncbi.nlm.nih.gov/gene/4909
TGFagastrointestinalhttps://pubchem.ncbi.nlm.nih.gov/gene/7039
TGF-ß1growth regulationhttps://pubchem.ncbi.nlm.nih.gov/gene/7040
TGF-ß3inflammation and immune systemhttps://pubchem.ncbi.nlm.nih.gov/gene/7043
PIGFgrowthhttps://pubchem.ncbi.nlm.nih.gov/gene/5228
VEGFAvasculature, inflammation regulationhttps://pubchem.ncbi.nlm.nih.gov/gene/7422
VEGF R2endothelial modulationhttps://pubchem.ncbi.nlm.nih.gov/gene/3791
VEGF R3vasculature, organ systemshttps://pubchem.ncbi.nlm.nih.gov/gene/2324
IL-1RAauto-immunehttps://pubchem.ncbi.nlm.nih.gov/gene/3552
IL-6auto-immune B cellshttps://pubchem.ncbi.nlm.nih.gov/gene/3569
IL-10immunoregulator intestinal tracthttps://pubchem.ncbi.nlm.nih.gov/gene/3586
IL-12inflammation and macrophage modulationhttps://pubchem.ncbi.nlm.nih.gov/gene/3593
TNF-RItumor suppressorhttps://pubchem.ncbi.nlm.nih.gov/protein/Q15628
TNF-RIIapoptosishttps://pubchem.ncbi.nlm.nih.gov/gene/7133
PDGF-Aplatelet and vasculature growthhttps://pubchem.ncbi.nlm.nih.gov/gene/5154
PDGF-Bmodulates soft and hard tissueshttps://pubchem.ncbi.nlm.nih.gov/gene/5155
TIMP-1cell health, cytokine activityhttps://pubchem.ncbi.nlm.nih.gov/gene/7076
TIMP-2cartilage and extracellular matrixhttps://pubchem.ncbi.nlm.nih.gov/gene/7077
HGFliverhttps://pubchem.ncbi.nlm.nih.gov/gene/3082
GDNFnerve survivalhttps://pubchem.ncbi.nlm.nih.gov/gene/2668
BDNFcentral nervous systemhttps://pubchem.ncbi.nlm.nih.gov/gene/627
FGF-4soft tissue repairhttps://pubchem.ncbi.nlm.nih.gov/gene/2249
FGF-7collagen and connective tissuehttps://pubchem.ncbi.nlm.nih.gov/gene/2252
IGFBP-1IGF binding proteinhttps://pubchem.ncbi.nlm.nih.gov/gene/3484
IGFBP-2T-cellhttps://pubchem.ncbi.nlm.nih.gov/gene/3485
IGFBP-3smooth musclehttps://pubchem.ncbi.nlm.nih.gov/gene/3486
IGFBP-4B-cell pancreashttps://pubchem.ncbi.nlm.nih.gov/gene/3487
IGFBP-6anti-tumorigenichttps://pubchem.ncbi.nlm.nih.gov/gene/3489
PTENtumor suppressorhttps://pubchem.ncbi.nlm.nih.gov/gene/5728
CSF3bone marrow and stem cellshttps://pubchem.ncbi.nlm.nih.gov/gene/1440
CCR1white blood cellshttps://pubchem.ncbi.nlm.nih.gov/gene/1230
MIGA1mitochondriahttps://pubchem.ncbi.nlm.nih.gov/gene/374986
NGFRnerve growthhttps://pubchem.ncbi.nlm.nih.gov/gene/4804
EGFRskin collagenhttps://pubchem.ncbi.nlm.nih.gov/gene/1956
GHmulti-tissue growth and metabolismhttps://pubchem.ncbi.nlm.nih.gov/gene/2688
IGF-1cell growthhttps://pubchem.ncbi.nlm.nih.gov/compound/16131429

Peer Reviewed Publications

Multi-Tissue DNA Aging & Methylation DNA methylation, histone modifications, and expression of regulatory noncoding RNAs are associated with tissue regeneration DNA methylation patterns change with age
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Safety